The exhortation to pray...first and foremost responsibility. I want to reiterate that prayer is HARD :). Not so we can be discouraged (or that I would be...), but that we realize that the battle is real, the opponents are real, and the weapons are warfare are not carnal but mighty to tear down strongholds (2 Cor. 10:4).
Listen, we CAN go through life without praying, but it doesn't make it a good idea. To borrow from Chris Rock, just because you can drive with one foot doesn't make it a good idea. We can certainly walk through day to day, in explicit "ministry," school, or work...but the living God isn't pervading our daily existence, how are our lives any different from those who don't consider themselves "like-Christ." We must pray, we must lay hold the throne of grace daily.
Prayer: Our First Responsibility
I rise before the dawning of the morning, and cry for help; I hope in Your word. My eyes are awake through the night watches, that I may= meditate on Your word.
Briefly, the way to escape religion as a front is to make it a fount. See to it that we pray more than we preach and we will never preach ourselves out. Stay with God in the secret place longer than we are with men in the public place and the fountain of our wisdom will never dry up. Keep our hearts open to the inflowing Spirit and we will not become exhausted by the outflow. Cultivate the acquaintance of God more than the friendship of men and we will always have abundance of bread to give to the hungry.
Our first responsibility is not to the public but to God and our own souls. God Tells the Man Who Cares, 115-116.